[Expert Solution]: Patients with liver disease may require…

Patients with liver disease may require anticoagulation for unrelated conditions, but little is known about its safety in these patients. Novel anticoagulants are not approved for use in patients with liver disease; thus, warfarin will likely continue to be the predominant agent used in this patient population. Understanding the risks of warfarin use in patients with liver disease would help inform clinical decision making. WHAT THE STUDY ADDS Patients with chronic liver disease receiving warfarin have poorer anticoagulation control and more bleeding, even after controlling for bleeding risk factors. However, these effects are not uniform, and specific laboratory values predict poor outcomes. A 4-point scoring system using albumin and creatinine can risk-stratify patients with liver disease in regard to risk of major hemorrhage while taking warfarin. Summarize above