[Expert Solution]: Which condition is most closely associated…

Which condition is most closely associated with a disturbance of neural crest? Clinical Correlation: Hirschsprung’s Disease Hirschsprung’s disease (congenital aganglionic megacolon) Failure of neural crest cells to migrate to distal Gl tract. Affected section of bowel is unable to perform peristalsis and paralyzed in the constricted state, resulting in fecal accumulation proximal to the aganglionic portion. Correctable by surgical resection of affected colon. colon R