The desired plasma level for an antiarrhythmic agent is 10 mcg/mL. The drug has an apparent volume of distribution of 17% of the body weight and an elimination half-life of 2 hours. An adult male patient (65 kg, 56 yo) is to be given an IV infusion of this drug. What loading dose (LD) and infusion rate ko would you suggest? The kinetics of the drug follows one compartment open model.
[Verified Answer]: The desired plasma level for an…
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