[Solved]: Drug X has a minimum effective concentration of 5 mg/L…

Drug X has a minimum effective concentration of 5 mg/L and a maximum safe concentration of 20 mg/L. The patients receiving the drug all have a volume of distribution of 27 L. The elimination half life of the drug is 8.5 h and the absorption half life is 1.5 h. Patient 1: Give a 490 mg intravenous infusion over 30 min, and follow the plasma drug concentration for the next 23.5 h. (To do this, give an infusion of 980 mg/h for 0.5 h, then change the dosage to zero for 23.5 h). Patient 2: Give a 245 mg intravenous infusion over 30 min, and follow the plasma drug concentration for the next 23.5 h. Patient 3: This patient has renal disease, causing the elimination half life of the drug to increase to 17h. Give this patient a 490 mg intravenous infusion over 30 min, and follow the plasma drug concentration for the next 23.5 h